Scientists in Israel have successfully conducted experiments on 250 mice, increasing their life expectancy by nearly 23%, which they believe can also be replicated in humans. Scientists have achieved these incredible results by increasing the supply of SIRT6, a protein that begins to decline with age. “These findings indicate that SIRT6 optimizes energy homeostasis in old age to delay weakness and maintain healthy aging,” the abstract reads.

The research titled “Recovering energy homeostasis through SIRT6 to extend healthy lifespan” has been published in the journal Nature Communications. It showed that compared with normal mice, the increased SIRT6 protein not only increased the life expectancy of subjects, but also made them look younger and less likely to develop cancer.

Professor Heim Cohen of Baylan University, who led the research team, said that the life expectancy of mice changed significantly after the experiment. He added that if the same jumps seen in mice are applied to humans, we can see that an ordinary person can live for up to 120 years. “The changes we see in rats may be transformed into humans, and if so, it would be exciting,” Cohen told The Israel Times.

This study is a collaborative study conducted by international scientists including Professor Rafael de Cabo from the National Institutes of Health. The study also shows that the increase in life expectancy of mice is not limited to any specific gender. However, the percentage increase in life expectancy of male and female mice is different. Although male mice with increased SIRT6 protein lived nearly 30% longer, female mice lived nearly 15% longer than mice that did not participate in the study.

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In view of Cohen’s experiments conducted in 2012, this new research is also of great significance, and Cohen subsequently became the first scientist to extend the life expectancy of male mice. However, the experiment had no effect on the life expectancy of female mice.

Cohen’s laboratory is now looking for innovative ways to conduct similar successful experiments on humans. Although mice have been genetically modified, scientists say that humans also need drugs. “We are developing small molecules that may increase SIRT6 levels or make existing amounts of proteins more active,” the scientist said. He expects to achieve concrete results in two to three years.


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